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Integrative weighted molecular network construction from transcriptomics and genome wide association data to identify shared genetic biomarkers for COPD and lung cancer.
Banaganapalli B, Mallah B, Alghamdi KS, Albaqami WF, Alshaer DS, Alrayes N, Elango R, Shaik NA. Banaganapalli B, et al. PLoS One. 2022 Oct 4;17(10):e0274629. doi: 10.1371/journal.pone.0274629. eCollection 2022. PLoS One. 2022. PMID: 36194576 Free PMC article.
The hub genes in the COPD network clusters were then queried in GWAS catalog and in several cancer expression databases to explore their pathogenic roles in lung cancers. The comparison of blood and lung tissue datasets revealed 63 shared DEGs. ...Interestingly, IRA …
The hub genes in the COPD network clusters were then queried in GWAS catalog and in several cancer expression databases to explore their pat …
The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the non-canonical Wnt pathway.
Abdelhamed ZA, Natarajan S, Wheway G, Inglehearn CF, Toomes C, Johnson CA, Jagger DJ. Abdelhamed ZA, et al. Dis Model Mech. 2015 Jun;8(6):527-41. doi: 10.1242/dmm.019083. Epub 2015 Apr 7. Dis Model Mech. 2015. PMID: 26035863 Free PMC article.
ROR2 also colocalises and interacts with TMEM67 at the ciliary transition zone. Additionally, the extracellular N-terminal domain of TMEM67 preferentially binds to Wnt5a in an in vitro binding assay. ...Wnt5a also inhibited both the Shh and canonical Wnt/beta-cateni …
ROR2 also colocalises and interacts with TMEM67 at the ciliary transition zone. Additionally, the extracellular N-terminal domain of …
Meckel-Gruber syndrome protein MKS3 is required for endoplasmic reticulum-associated degradation of surfactant protein C.
Wang M, Bridges JP, Na CL, Xu Y, Weaver TE. Wang M, et al. J Biol Chem. 2009 Nov 27;284(48):33377-83. doi: 10.1074/jbc.M109.034371. Epub 2009 Oct 8. J Biol Chem. 2009. PMID: 19815549 Free PMC article.
Autosomal dominant mutations in the SFTPC gene are associated with idiopathic pulmonary fibrosis, a progressive lethal interstitial lung disease. Mutations that cause misfolding of the encoded proprotein surfactant protein C (SP-C) trigger endoplasmic reticulum (ER)-associ …
Autosomal dominant mutations in the SFTPC gene are associated with idiopathic pulmonary fibrosis, a progressive lethal interstitial lung